London, United Kingdom
Growth Hormone Receptor, Molecular Model
Ramon Andrade 3dciencia
Photograph - Photograph
Growth hormone receptor. Molecular model of a growth hormone receptor (orange and beige) bound to a growth hormone molecule (pink, centre). Binding of growth hormone rotates the receptor molecule subunits, changing the alignment of the intracellular (bottom) part of the protein. This activates the tyrosine kinase JAK2 (pink, bottom right), which initiates a number of changes within the cell that activate specific genes. Growth hormone stimulates growth, especially in childhood, strengthens bone, increases muscle mass, reduces glucose uptake by the liver and promotes the breakdown of body fat.
May 6th, 2013
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