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Cancer Cell Death Sequence, Sem
Photograph - Photograph
The initial stages of the death of a cancer cell. A cancer cell (green) has migrated through the holes of a matrix coated membrane from the top to the bottom, simulating natural migration of an invading cancer cell between, and sometimes through, the vascular endothelium. Notice the spikes or pseudopodia that are characteristic of an invading cancer cell (1). A buffy coat containing macrophages (pink), lymphocytes (blue), and red blood cells (red) is added to the bottom of the membrane. A group of macrophages identify the cancer cell as foreign matter and start to stick to the cancer cell, which still has its spikes (2). Macrophages begin to fuse with, and inject its toxins into, the cancer cell (3). Eventually, as the macrophages take over, the cancer cell will its morphology, shrink up and die. Magnification (left to right) x12,000; x4,000; x8,000. Enhancements of BJ4579, BS9471, and BS9472.
March 7th, 2013
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