Prions could enter the brain along the axons of neurons. This probably happens by a retrograde flow of prion filled vesicles. These are shown in the picture as purple spheres ascending the axon like elevators going up a shaft . Another route of entry could be the blood, probably in immune cells. A lymphocyte is shown exiting the capillary at bottom left where it could then contact the astrocyte. Astrocytes and other glial cells also support the production of prions.
August 7th, 2012
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