London, United Kingdom
Triose Phosphate Isomerase Molecule
Dr Tim Evans
Photograph - Photograph
Triose phosphate isomerase (TPI) molecule. Computer model showing the shape (secondary structure) of the a molecule of the enzyme TPI. Seen here are alpha helices (coils), beta sheets (arrows) and linking regions (lines). TPI is essential for glycolysis and catalyses the reversible interconversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. This conversion allows all products of the initial glucose molecule to be further metabolised for maximum energy yield. In humans, deficiencies in TPI are associated with a progressive, severe neurological disorder called triose phosphate isomerase deficiency.
May 7th, 2013
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